Endocrine Abstracts

Background: Patients with pituitary disease demonstrated Quality of Life (QoL) impairment. From other chronic diseases it is known that partners of patients also report impairments in QoL. Furthermore, it is observed that well-being of patients is associated with the well-being of their partners. To date, no data are available on the well-being of partners of patients with pituitary disease. Therefore, the aim of the present study was to explore well-being of partners of patie...

Introduction: Thyroid dysfunction may cause various psychiatric symptoms and disturbances. In addition, many factors affect the variable responses to hormone replacement. Many patients treated for Hashimoto thyroiditis(HT) report persistent impairments in general well-being despite long-term L-thyroxine (LT4) replacement and restoration of biochemical euthyroidism.Aim: To investigate the prevalence of depression and anxiety in patients with HT on long-te...

Introduction: There is an increasing awareness for intrinsic imperfections of endocrine replacement therapy affecting general well-being in the long-term. For thyroid hormone, many factors affect the variable responses to hormone replacement, like common genetic variations in deiodinase and thyroid hormone transport proteins, and the inability to provide adequate individual combined T4 and T3 therapy. Despite levothyroxine (L-T4)...

Background: An increasing number of studies assess quality of life (QoL) in patients with pituitary diseases. At present, available disease-specific QoL questionnaires do not completely cover the patient perspective of QoL. Furthermore, there are no disease-specific questionnaires available which inventories patient’s needs for help for impairments in QoL.Objective: To develop and validate a disease-specific QoL questionnaire for patients with pitui...

Introduction: Full blood count (FBC), C-reactive protein (CRP), albumin and serum inflammation-based scores reflect systemic inflammation and predict outcomes in oncological patients. While these are increasingly used in cancer, little is known in pituitary adenomas (PAs). We aimed to characterise FBC and inflammation-based scores in patients with PAs and investigate the usefulness of such parameters in predicting aggressive/refractory disease.Methods: W...

Objective: Psychopathology and maladaptive personality traits are often observed during the active phase of Cushing’s disease (CD). We hypothesized that patients with long-term cure of CD show persistent psychopathology and maladaptive personality traits.Aim: To evaluate psychopathology and personality traits in patients with long-term cure of CD.Patients and methods: We included 67 patients cured of CD (15% males, mean age 53...

Objective: Treatment with ergot-derived dopamine agonists, pergolide and cabergoline, has been associated with an increased frequency of valvular heart disease in Parkinson’s disease. The aim of the present study was to assess the prevalence of valvular heart disease in patients treated with dopamine agonists for prolactinomas.Design: Cross-sectional study.Patients: We performed conventional two-dimensional and Doppler echocar...

Purpose: The condition of pituitary apoplexy contains the clinical spectre from life-threatening emergency to a condition with chronic symptoms and self-limiting course, which partly determines diagnostic delay and management. Outcome evaluation of course and management of pituitary apoplexy is hampered by the diverse presentation of this condition and requires appraisal. This study aimed to describe the patient journey, clinical presentation and management of various types of...

Objective: Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) excess results in both reversible and irreversible damage to the skeleton, and includes increased vertebral fracture (VF) risk in the presence of normal BMD. The prevalence of VFs is approximately 60% in controlled acromegaly patients, and these VFs can progress during short-term follow-up. We aimed to identify the course of VFs and their associated risk factors in a cohort of acromegaly patients in long-t...

Objective: Self-reported volume of patients and specific interventions is a specific network criterion that needs to be fulfilled by reference centres that are eligible for inclusion within Endo-ERN. The aim of the present study is to evaluate how self-reported volume data in the original applications were obtained, which data are retrievable, and which set is best suitable to use for future centre evaluations. This overview is provided for two Main Thematic Groups (MTGs) of E...